Dr. august ames gives you the sexual healing youve been needing.

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Not bad at all. I had a heart attack four years ago which until I got on a physio course, I was very sedentary, not even believing I could get back into real physical activity bluntly, I was afraid to.

Before the heart attack I was about ks. Oh, and I smoked Gitanes for 50 years that might have something to do with it.

I gave up about 6 yrs ago. As to diet? Not that it matters that much as all carbs turn to glucose anyway.

But, I never eat processed foods at all or ready-made dinners etc, or fizzy drinks and I drink booze only rarely. And finances permitting, I buy organic veggies, eat lots broccoli, garlic and ginger and fermented soya as well a range of spices from fenugreek to coriander pretty much every day.

What strikes me most about the all the fascinating contributions here, is that the common denominator to what ails us is Western, industrial capitalism which has bombarded our bodies and our minds with who knows what crap for at least years.

This is why I visit this site. I rarely ever get colds and never get the flu. I can remember my mum putting a capful of Dettol in the bath as a kid, but that was it.

I got my daily dose of cod liver oil, orange juice and free milk for my first ten years of life, making me probably part of the healthiest generation of working class kids this country has ever seen thanks in large measure to the Red, Prof Haldane, who worked out the wartime diet.

At high school we had compulsory sports every week which I hated but I was a promising athlete, who did nothing with it. Back then, Asthma was not all common, nor were the allergies so many people suffer from today.

Frankly, I say that capitalism has completely poisoned us and our planet. What, and how much, are two different issues.

I would also suggest looking up Per Bjorntorp on pubmed and reading his work. You may also like to look into drugs for psychotic illness and their impact on weight.

You really can be an enigma. Your conclusion still needs explaining. Bob Just back from five weeks in Normandy, during which time I ate more bread, fatty meat and fruit and veg than normal, but ate less fish.

My BP is down as is my weight and slight arrythmias have disappeared. Go figure. I think modern American society refutes the notion that being obese has nothing to do with what you eat.

As do photos from WWII concentration camps. WW11 concentration camps merely highlight that how much you eat can be of over-riding importance.

But I still think that what you eat has effect on weight. As far as I know no one ran an RCT comparing calorie to calorie diet of processed foods vs whole foods but certain things can be inferred.

There are a lot of data that gut microbiome is influenced by the type of foods we eat and there are also data that microbiome influences weight.

Besides, the whole weight debate is academic. The thing that has struck me in the mountain of comments is the intense focus on diet, and the attention to detail in the micro-nutrients and supplements.

This so clearly parallels the attention to detail of the medical tribe who want to force feed four mutually incompatible chemicals and imagine that will sort the problem.

There is some good in all approaches, but more in some than others. We need more who can lean back and see the big picture. I would really laugh my socks off if I were to find that some of my feeling ill was due to a sneaky little cancer, flying below the radar.

I mean that: I would laugh. But diet might well affect Type 2 diabetes. I can corroborate that: after religiously following the GP recommended high carb low fat diet along with simvastatin, I became pre- and then full on T2D.

I was told to continue on the same diet and the statin, but that even so, diabetes was always progressive and I would need medication by the end of the year.

It seemed utter madness to continue with the same regime that had brought me to this place in the full acknowledgement that my health would deteriorate however strictly I followed the given diet and drug.

Immediately stopped the statin and started on his recommended diet, and found that thereafter, to the astonishment of my diabetic nurse, my A1hbc became normal, and stayed in the normal range.

All anecdotal, of course, but many anecdotes make cumulative case history evidence, I think. If diet can have such a strong effect on T2D, which in itself tends to lead to CVD, we could be forgiven for thinking that Keys was wrong with his fat hypothesis, but Bernstein was right with his… We are all agog, Dr K, for what does cause CVD, and what, if anything, we can do to prevent it.

Jack, I used to take meds for HBP, but the first one made me cough and the second made me dizzy. And I still had high BP. So I stopped trying to reduce my BP artificially, and tried to improve things with a LBHF diet, which I follow anyway to control my diabetes, successfully!

This seems to be a common story but totally ignored by the medical establishment; it simply does not fit the gospel, ergo it must be wrong!

When bit by bit I became diabetic, after taking simvastatin for 3 years, I had to find out why it was that I was that I might end up with amputated limbs.

So I started on the cut the carb bread, potatoes, rice, pasta, juices. I was well into this when I met with the diabetes nurse.

What has fat got to do with my glucose levels? Ignored her advice to eat plenty of pasta Mediterranean diet and whole grains.

I too gave up statins, in my case because I ended up with muscle damage. At the same time I discovered that one side effect of statins was new onset diabetes.

On the diet causing CVD: At the time when I read about the dangers of high blood glucose levels the notion of LDL particles invading an artery wall seemed unlikely.

This was all the more likely when I learnt that coronary artery walls have their own capillary system supplying the smooth muscle. So the same scenario as limb-loss might occur in the capillaries in the wall of the artery.

So, on this basis having a diet that leads to a high glucose level seemed to be more of a problem than LDL particles.

Weight is only an issue if it causes glucose levels to rise. It seems to me more likely to occur on the capillaries in the wall of the artery.

Then the other elements of inflammatory defence kick-in. I suspect that over-zealous immune processes are the cause of CVD. Antony Sanderson, your story does indeed seem very similar to mine.

When she discovered how I controlled my diabetes, dropping statins, going LCHF she became interested and helpful.

Oh dear, and I had convinced myself that diet is the key. Should I be rereading it? The psychologist Ronald Grossarth-Maticek established a study group of people aged approx 50 who were assessed as being prone to stress.

An experimental group was given 6 hours of therapy designed to reduce stress levels while an equal sized control group was given the same amount of personal interaction but with no intent to reduce stress.

After 10 years the control group had 11 cancer deaths for every one in the experimental group and 5 CVD deaths for every one in the reduced stress group.

MalcolmS, if it sounds too good to be true, it probably is. Since the good man did most of his work in Germany, there is quite some stuff to be found in German, so I had a chance to read up.

I suspect that serious questions about double blinding can be asked. Hans Eysenck had similar results: a marked reduction in cancers among a group who received psychological training on how to deal with stress.

But he has always been controversial; maybe they were afraid that adopting his theories would be career-killers. The numerical results from therapy would be reduced by a FACTOR of about 20 if applied to an average unselected population.

If not double blinded, psychological effects typically swamp the therapeutic benefits of so-called powerful drugs when trialled. Conversely, stress itself can cause increased depletion of these minerals…hence the need for a daily intake.

I love your blogs though — maybe put them into a book? In my mind there must though be some connection Hippocratic?

They do. He does make the point that we have little knowledge of what causes diseases, and our ability to treat them has been accidental.

Okay, you have laid down the gauntlet — if CVD is not primarily due to diet, what is it due to? I come from a family with a terrible history of CVD.

Often it struck as young as My father, a strict vegan for much of his adult life, made it to He too, believed CVD was affected by diet, and that vegetarianism would be the key.

Unfortunately, it was not the answer, and he fell a few years short of his father, who made it to the ripe old age of I look great.

I feel awful. Being a strict Vegan does not mean a healthy diet. I would be interested to know more about him and what he ate.

After reading this blog for some time, as a non-medical outsider, I think you are absolutely right! I remember joking that those blaming saturated fat would start dissect fats into all their individual fatty acids — and sure enough that is exactly what they are doing!

Many people claim that carbohydrates are completely evil and unnatural, but then I was given a link to an article in the comments that claimed that honey was beneficial!

There are also places that use rice as a staple food. Furthermore, one of the major advances in human history was the cultivation of grain!

As you also say, CVD rates are still falling — so surely this is where researchers should look for a cause of CVD — it has to be something that we do less of now, or something beneficial that we do more of!

Maybe CVD rates fall with the rise in the use of electronic equipment! Some of the diets on offer here sound awful, and I imagine those who keep to them can never go out for a meal, and probably spend most of their time sourcing the right ingredients.

I think that anybody who advocates a diet hypothesis should think first at the amazing contrast between Scotland and France. Click to access bhf-trends-in-coronary-heart-disease.

Remember that Malcolm pointed out that the CVD risk calcuators are now massively pessimistic because they have not been updated to reflect this change.

Thanks for the link David, very interesting that the incidence of MI seems to have decreased since its peak in the mid s….

My best guess for the decrease would be the reduction in smoking rates since that time, and also possibly that nutrition levels have improved many of those dying in the s would have grown up during and around the 2 world wars.

He explains how these risk calculations have not changed over the years, and so are now seriously pessimistic!

The risk calculators obviously include whether people smoke or not, and they are still wrong! I mean I suppose one wild guess might be that some unsuspected bacteria or virus is involved in the CVD process, and is now less prevalent in the West.

The unexpected fact that bacteria cause most stomach ulcers might make that idea a bit more plausible. Also, I seem to remember hearing that people with serious gum infections are more likely to suffer CVD events — which again might implicate bacteria.

While H pylori does cause ulcers and stomach cancer in some people, in others it may actually have beneficial effect, protecting against developing asthma and allergies.

I ask for the steak and for a garden salads, some extra butter and nothing else and have never had any problem. Quite apart from matters of enjoyment, I also think you are far more likely to miss out on some essential mineral or vitamin on a highly restrictive diet.

Real butter though. I suspect the prettily shaped buds of garlic and herb butter that get served are often spreads rather than butter.

In science we disprove hypotheses. The diet hypothesis has been disproven numerous times. So we need to stop trying to make that hypothesis work and come up with new ones.

I also agree with you on people becoming diabetic and then obese. Its like the non-fat cells are starved for nutrition so the person feels hungry.

They eat and then the nutrition gets absorbed by the fat and the person gets fatter. So the non-fat cells are still starved, so the person eats and the nutrition gets absorbed by the fat and ….

Its a bit like an organization where the workers are underpaid so they complain and the company is given more money. The administrative department takes the extra money and gets bigger.

The workers are still underpaid so they complain and the organization is given more money. And, the administrative department takes the extra money and gets even bigger, ….

Societal diabetes maybe? But I digress. Back to diabetes and obesity. The obese, diabetic person is in a terrible bind. They are really hungry.

A lot of their body cells are not getting nutrition. Their need to eat is not a lack of will-power, it comes from a legitimate need for nutrition.

But the cells that need the nutrition are not getting it. The only way out of this loop for the diabetic, obese person is to find a way for the non-fat cells to get more nutrition.

Its not about calories in and calories out. Enjoyable physical activity and less psychosocial stress seem to help in this regard.

Sorry to go off topic. I am enjoying your posts very much. Thank you for all the time you put into them. Diet may or not be important if you have robust genetics.

If you think its all down to genetics ow do you explain the fact that low incidence of HD in Japanese pre ish was overturned as soon as they moved to Hawai and adopted an American diet.

No amount of genetic makeup seemed to safeguard them. The next step of the dug companies is to convince us that genetics is the answer and that they can isolate your achilles heel gene early and hence get you on drugs from a much earlier age.

On top of that, they had to cope with the stress of moving to a vastly different country. This theory does not really hold with the increase in CD in Uganda where previously it was unheard of.

I think stress plays a part but so does diet, the latter is easier to control. In Ugandan villages increased urbanisation was measured from village to village.

These people did not experience displacement. Varying increases in HD were found. So perhaps eventually a higher simple carbs diet will lead to CVD, via diabetes, a route that can be avoided by many.

It would seem prudent to eat real food cooked from scratch rather than burgers and chips throughout your lifetime. Maybe there really is something in the diet thing.

What else has paralleled the fall in CVD, something in the water, the air. Dr Kendrick, can we ever know, and failing going to live in France, how do we mitigate this debilitating illness in the developed world.

Thank you. Surely the point is that we tend to talk about CVD as if it were a worsening problem, that could reasonably be associated with something we do differently now — like eating burgers.

However we need to explain why CVD incidence is actually going down — not up! The propaganda from the health lobby can give the impression that CVD is becoming more common, but as Dr Kendrick has pointed out, those CVD risk calculators were calibrated many years ago, and are now seriously pessimistic!

Yes I do take your point. Yes I understand it is falling, but is it static, still meet lots of sufferers, some in my family. I am certainly of the view that lifestyle and good nutrition play a large part, stress, my children and many others of course work long, travel far, live with insecurity.

Could the attraction and persistence of the diet hypothesis be explained by our need to believe we can control disease and ageing?

I would guess that a lot of contributors on this Comment Page are of a similar generation and one that looks for hope and some empowerment in the dietary ideas offered by followers of this and similar blogs.

Whatever else we may gain from your articles Dr Kendrick, understanding grows when we share and adjust our thinking. Thank you! Actually, I found your last post regarding stress as a the?

I may be obese, but I am nowhere remotely near diabetic, and managing carbs helps manage weight. My father died of a heart attack the day after my mum died of cancer — that was just too much stress!

Sarah, Stress is a major contributor to obesity. Abdominal fat seems to be a way the body tries to protect itself when under stress.

Unfortunately, that means that getting stressed about being obese is just going to make it harder to lose weight.

We have to implement weight control methods without putting even more stress on ourselves. The crux of his Nobel thesis was that malignant tumours frequently exhibit an in-crease in anaerobic metabolism compared with normal tissues.

And that in turn means that cancer cells are dependent on glucose for growth. All cells can use glucose, but cancer cells consume as much as four or five times more than normal, healthy cells.

In fact, cancer cells seem to have great difficulty surviving without glucose. A study carried out by Johns Hopkins researchers found evidence that some cancer cells are such incredible sugar junkies that they will self-destruct when deprived of glucose.

The waste products of the process are carbon dioxide and water. The process by which cancer cells derive their energy is one of anaerobic fermentation of glucose, with lactic acid as a waste product.

The lactic acid produced is then transported to the liver where it is processed into glucose, ensuring the cancer cells have a constant supply of energy.

The cancer is wasting energy, and the patient becomes tired and undernourished. The famous 19th century cancer specialist, Dr Stanislaw Tanchou, presented the first formula for predicting cancer risk in a paper delivered to the Paris Medical Society in The more grain consumed, the greater the rate of cancer.

Can low-carb diets prevent cancer? If cancers cannot survive without glucose, surely it follows that a low-carb, high-fat diet is likely to prevent a cancer starting.

Just that piece of knowledge might stop all the heartbreak, pain and misery that cancer causes. Two of the most common cancers are breast cancer — which, incidentally, is not confined to women — and lung cancer.

In the context of blood sugar and cancer risk, it may be significant that UK research suggests that people with coeliac disease — and who do not eat wheat and other cereals — have only about one-third the risk of either of these cancers.

Furthermore, an epidemiological study in 21 industrialized countries in Europe. North America and Asia, revealed that sugar intake is a strong risk factor that contributes to higher breast cancer rates, particularly in older women.

Insulin and cancer Blood concentrations of fasting insulin, glucose, cholesterol and triglycerides in non-obese people suffering from colon, stomach and breast cancer were determined and compared with those of healthy non-obese people.

Insulin was also measured in tumours and non-cancerous tissues. Insulin and glucose with the exception of glucose in colon patients were significantly higher than in healthy people; blood cholesterol and triglycerides levels were lower.

Tumours contained 1. Cancer therapies should encompass regulating blood-glucose levels. This is best done via diet, supplements, and non-oral solutions for those.

References Chapter Twenty — Three — Cancer — disease of civilization Warburg O. On the origin of cancer cells. Science Shim H, et al.

Rossi-Fanelli F, et al. Abnormal substrate metabolism and nutritional strategies in cancer management. J Parenter Enteral Nutr ; Grant JP.

Proper use and recognized role of TPN in the cancer patient. A ; 6 4 Suppl : 6S-7S, 10S. Pedersen PL. Tumor mitochondria and the bioenergetics of cancer cells.

Exp Tumor Res , Tanchou S. Gaz d hop Par ; West J, et al. Malignancy and mortality in people with coeliac population based cohort study. BMJ ; Seeley S, Diet and breast cancer; the possible connection with sugar consumption, Med Hyp ; Moerman CJ, el al.

Dietary sugar intake in the aetiology of biliary tract cancer. Int J Epidemiology Yam D, et al. Hyperinsulinemia in colon, stomach and breast cancer patients.

Cancer Lett ; Selective quotatation of of reference [22]. This is a very puzzling result. It could mean that only these two cancers exhibit significant Warburg effect, which seems unlikely.

The overall hazard ratios were: for any malignancy 1. The increased risk was primarily in the first year after diagnosis, with the risk for only lymphoproliferative disease remaining significantly raised thereafter.

After excluding events in the year after diagnosis, the hazard ratio for malignancy was 1. This is unfortunately not true, or not the whole truth.

Cancer cells are also fueled by proteins or fats or ketones. They just need a bit time to adapt from one food source to another. Diana, are you saying Warburg was only partially correct?

Thanks so much. Such an ancient parasite as cancer will eat just anything. Excessive lipids and cholesterol in cancer cells are stored in lipid droplets LDs , and high LDs and stored-cholesteryl ester content in tumors11, 12, 13, 14 are now considered as hallmarks of cancer aggressiveness.

Paradoxically, some cancer cell lines also display addiction to glutamine despite the fact that glutamine is a nonessential amino acid that can be synthesized from glucose.

The high rate of glutamine uptake exhibited by glutamine-dependent cells does not appear to result solely from its role as a nitrogen donor in nucleotide and amino acid biosynthesis.

Instead, glutamine plays a required role in the uptake of essential amino acid and in maintaining activation of TOR kinase.

Moreover, in many cancer cells, glutamine is the primary mitochondrial substrate and is required to maintain mitochondrial membrane potential and integrity as well as support of the NADPH production needed for redox control and macromolecular synthesis.

As such, ketone inhibitors should be designed as novel therapeutics to effectively treat advanced cancer patients, with tumor recurrence and metastatic disease.

This book, and reading a few things about the Warburg effect, still left me with the impression that all PET active cancers can be attacked by lowering glucose levels or disrupting glycolysis, and that those that are not PET active are slowly proliferating anyway.

I wonder if an approach similar to the use of multiple antibiotics is possible, in that the cancer is first driven into specialisation by a dietary change or some disruptor, and then killed off by another change that would not have killed the initial population prior to the first change.

How do I do it? Yes, there is clearly something else going on than too much glucose. Thanks everyone for all the comments whilst I have been away.

Seems to have been a very interesting discussion. Andy Harcombe had been approving comments for me. So thanks to him for this.

More work than he was expecting. It is great that everyone is so engaged and interested. Diana, I was thinking along the lines of e.

This is the beauty of this blog, that posts can take one in unexpected directions…. Yes, unexpected directions, but I think we have crossed the line again.

Enough of cancer. Kendrick: Bravo. Just joking. Very interested to see where your thinking is heading. Dr Kendrick, it seems we are still unable to itemise specific foodstuffs regarding cardiac problems, or many other maladies afflicting human beings.

By the time I am 70, I will have experienced many forms of illnesses causing death to close family members, young and old, close and distant acquaintances, short-stay and long-term patients in my care, and the countless unknown to me individuals who made it into the Times Obits, or the tail end of the BBC news.

There have been rich and poor. Tall and small. Fat and thin. Active and sedentary. Smokers and non-smokers. Drinkers and abstainers.

Intelligent and not-so bright. Saints and sinners. On and on. We will all die one day, but we are seeking to find the triggers causing poor health, so that we can avoid them, whilst looking for the elements which keep us healthy for as long as possible.

I conclude that these 2 lists are unlikely to overlap, and only by reading round the subjects of food and lifestyle choices, are we going to come up with a semblance of truth.

After all, it is not that long ago maybe 60 years or so , that some patients were being advised by GPs to smoke, making the Ancel Keys contribution to good health seem pretty benign in comparison!

My point? Please keep stimulating responses to your blog…. It is for us to choose who we think is the sincerest.

Just to throw a spanner in the works though….. And even more problematic……….. Though not in a way we can generalize. Everyone is different.

One skinny person can eat ice cream and not gain a pound, whereas if I look at a delicious bowl, I gain 2 pounds! The secret is finding out what diet and general foods, carbs, meats, etc.

If we listen to what our body is telling us, i. Ancel Keys supposedly changed his mind about saturated fat later in life, according to Dr.

His famous 7 country study was really a 22 country study, he just ignored the other 15 which had higher amounts of fat in the diet.

Not exactly sure and how he got away with it is even more astounding. Would it be fair to say that Ancel Keys, abetted by government health propaganda, shortened more lives than Mao?

I fear it might be. Almost everything is caused by genes or germs. By the word diet are you ruling out nutritional value in our western diet.

I am anxious to see the comments on this one. If you eliminate diet as a useful tool for controlling heart disease, you take away what we feel we have some direct daily control over.

So, if not diet, then what? What factors can we actually take control of that will make the most difference?

Any difference? Low carb has huge benefits. I did a low carb diet for nearly two years because of the supposed advantage for endurance sport I cycle long distances.

But worse, it caused my heart rate to reduce and become erratic and for my body temperature to reduce. The final straw was when I collapsed due to the erratic heart rhythm and ended up in hospital.

They wanted me to have a pacemaker but I proved on a 5 day ECG Holter monitor that my rate and rhythm are normal on a high carb diet, donthey discharged me.

Or is that too simplistic? Our obsession with control through diet and other things in our lives causes stress which causes issues in the body CVD, Cancer, etc.

I am reading with great interest. They have done so for thousands of years. Sugar consumption has stagnated for quite some years now in most Western countries.

At a horrendous level, for sure. Mortality is a different story, but here treatment and other factors come into play. This is well within physiological norms.

And both are biochemically known to dramatically worsen our cardiovascular and overall health. Andrew, I agree entirely with you….

Catching your drift Dr K. As far as your a posts on heart disease are concerned you must be getting frustrated.

Diet does make a difference, but not necessarily here. So diabetes is not related to diet either? But I can easily believe that CVD is less affected by the particulars of what Blue Zoners eat than by their tight social communities, sunshine, exercise as part of daily life, etc.

One question: If CVD is caused by clotting problems, and some foods affect clotting omega 3s, vit K foods, etc.

I guess I still find it hard to imagine that dietary factors make NO difference since we are, to some extent, what we eat.

It certainly is true that years of micro-analysis of vitamins, nutrients, antioxidants, etc. No consensus.

It gets exhausting!! I think it makes good sense to approach the question of health and disease from cell centric perspectives rather than dietary ones.

If all our cells remain healthy then so do we. But if cells become sick then the tissues and organs they comprise may trend to sickness and diseases too.

Might it be the case that one of more factors could compromise cells ability to regenerate in precisely their own likeness?

Imprecise regeneration over successive generations of cells could then account for degeneration of cells with cells losing some of their specificity of purpose and function given to that type.

Cells start out in life as totipotent types that lack the necessary differentiation to account for the many types of cells that will develop as an embryo advances to become a foetus, as foetus advances to become a baby, and as a baby is born, becomes a child attains status of adult.

Robert O Becker did much pioneering research work on regeneration. He did so with the hope of being able to stimulate regeneration in the case of fractures where the process of regeneration and healing had stalled.

He did enjoy some successful outcomes in last chance patients. He established that the way cells regenerate may be influenced by the electrical environment that persists in the tissues that surround them.

The above should have the minds of truly interested parties wonder about the part that resting potential of cells may play in the regeneration of cells.

When the resting potential of cells is adequate cells regenerate with precision and maintain their allotted differentiation of type.

If the resting potential of cells declines it has been suggested they trend away from their allotted differentiation. Pertinent to the above is that oxygen is a potent stealer of electrons; while Earth is the great donor of electrons.

They are ions in other words and are typically represented by ions that are negatively charged. So if you collect exhaled breath, condense it, and test for pH the test will indicate alkalinity.

Exhaled breath condensates EBCs are typically alkaline. When a solution tests as alkaline that indicates net electro-negativity.

The net electro-negativity suggests oxygen breathing species lose electrons with every exhaled breath. This is the root of oxidative stress.

If electrons are being stolen from within us as ionised oxygen species because oxygen is a potent robber of electrons then that leaves aspects within us within our inner soup of biochemistry deficient in electrons.

There is simple visual analysis of blood samples that suggests oxidative stress of this kind results in a decline of zeta potential of blood cells.

Zeta potential and resting potential of cells amounts to the same thing, albeit set in contrasting contexts.

Blood cells equate to colloidal particles, and its adequate zeta potential that keeps colloidal particles in suspension.

Ergo earthing restored zeta potential to blood cells. Our progenitors and ancestors never had to concern themselves with oxidative stress. Just so long as they went about business as usual while being barefoot of shod with footwear crafted from natural materials then as fast as electrons exited the body with every exhaled breath replacement electrons could be sucked up through the soles of the feet from natures great electron donor, Earth.

Any tendency to assimilate electro-positivity within them and their inner soup was countered by the rise of electrons flowing from ground, through the feet, and into them.

Of course, the construction of dwellings has changed over the years, as has the extent and means to furnish them, and the construction of modern footwear now rarely utilises natural materials.

Instead rubber and plastic dominate. The modern human now has has effective contact with the great electron donor only on the rarest of occasions.

What has happened is that technological progress has sealed our fate. Oxidative stress is a natural phenomenon attributable to the properties of oxygen and the configuration of electrons in its outer shell.

The natural phenomenon that arises in all creatures that breathe air has a natural antidote. But in modernity we have lost the former traces and vestibules of effective contact.

Oxidative stress is a problem for us now when it never was before. Aspects of our inner soup that ought not to be electro-positive can trend that way so long as we remain so isolated from the great electron donor.

One very likely and significant prospect is that cells suffer decline of resting potential. If resting potential is chronically suppressed regeneration of cells will proceed, perhaps, in away that permits degeneration over successive generations.

So tissues and organs may suffer degeneration, then when they do we get sick and sicker. Now epidemiologist could turn their hand to something useful.

Those people who live in parts of the world where it is usual to go about business barefoot, or wearing footwear crafted from more natural materials, could be compared with the rest of us.

I consider an earthing sheet is a worthy investment. If they were able my cells would thank me for it. Interesting post Christopher, I have an earthed mouse mat and would love to source leather soled casual shoes, alas I may have to get some made.

The more I learn in this reading too difficult for medical students? Categorical statements make me revolt! This issue of the rise and fall of historic, reported CVD rates as a pointer to cause is confounding it seems to me.

If stress is a driving factor are we thinking that recent falls in rate reflect a lowering of stress at the population level?

It has been suggested that CVD may be communicable and that we are looking at an epidemic that is fading. It could be that aggregated data over a population is insufficiently granular.

CVD is tied to social class, gender etc. Perhaps the falling rate reflects inner shifts in the make up of the measured population?

And, of course as Dr. Kendrick as pointed to reporting inconsistencies. I have compiled a list of all Dr. Kendrick, thanks for all your good work!

Keep it up. I do wish he would somehow make the full list available — even by simply including a link to your list.

Igor, thank you ever so much for taking the time to compile this list and for sharing it with the rest of us. Thank you Dr Kendrick, I suspected as much regarding diet.

Totally intriguing. Lyon Renaud, de Lorgeril, et. Equally, if CVD is mainly caused by diet, how do you explain the French anomaly, or the fact that rice is a staple food for many people, or the fact that CVD rates have declined over many years?

Biochemistry is immensely complex — even before you factor in the bacteria in our guts — and yet something as simple simple as a cause, but the biochemistry will be complicated as stress clearly has a huge effect on CVD rates.

We are omnivores, and that must mean that our bodies have a lot of tolerance of variations of diet. Some of that has come out in these blog discussions — the innumerable feedback loops in the body that mean, for example, that if we consume more cholesterol, the liver makes less, or if we consume a little more salt, it is excreted etc etc.

So in this case, because the focus has been on diet, the models all relate to food. If the focus had been on the strict observance of religious rituals, I have little doubt that provided those rituals had enough complexity, someone would have made an excellent case that non-observance of this or that rite explained CVD!

There is a rough analogy with trying to fit some data to a formula with too many adjustable parameters. I realize the discussion is about CVD.

Keep in mind though, there are very good reasons to keep carbs within your tolerance and eat more fat. From a presentation by Jeff Volek today:.

Excellent series to maintain periodic motivation to search for answers. At 76 years it is important to slow down the ageing process asap.

My present beliefs about health always open to change is to follow the low carb diet. Then how much and when to eat has to be considered.

Thinking at the cell level can provide answers. Intermittent fasting such as Fast-5 gives cells a chance to rest and self clean via mTor regulated autophagy.

Keeping mitochondria happy is also important, adequate Mg and avoid linoleic acid. Stressed cells communicate their status to the liver and other organs and get an appropriate response.

Very complicated process and not fully understood, much more to learn how the body functions. In the meantime follow some basic principles that work for you.

Are supplements a waste of time as well. Tried everything to reduce my bp even low carb. Has Ornish since he published in The Lancet in been telling a complete load of porkies and diet has had little effect.

Men have far more heart disease than women. My intuition is that diet and lifestyle do matter, in complicated ways for different people.

Medicine is a special type of food also and while it might not be anywhere near as effective as we have been lead to believe, I would probably not be alive without metformin and big lifestyle changes.

Imagine that a similar pattern was relevant to cvd risk. In a population the genetic variants would be randomly distributed, the susceptibilities all mixed around.

Those who had a healthy upbringing even with the high risk genes might live long healthy lives, maximising their potential. Those who have bad diet or unfortunate diseases might not, even with hardier genetics.

A simple model based on that has two independent random variables ie susceptibility vs environment with the susceptibility heing truly random but the environment governed by lots of strange things that can vary widely by region; culture, diet, disease prevalence, family background, wealth, quality of health care ….

You have to rely on population statistics when what you really want to understand is individuals. Perhaps even not logical.

It certainly is possible to eat too much of any diet and what if you have a hfhchp highfathighcarbhighprotein hotchpotch with lots of badly prepared ingredients of dubious quality?

Not to mention a diet of statins. I get it now. This is Dr. Kendrick as agent provocateur. I predict at least comments for this post. Men get it more than women.

Older people get it more than younger people. Something to do with clotting. Nothing to do with diet. Virtually unknown before Rising to a peak in and falling away rapidly.

Grimes that an organism caused the CVD epidemic and it has run its course. Is it accepted that coronary artery plaques lead to blood supply insufficiency lead to heart muscle death, therefore it is enough to explain the formation of plaques?

On a subscription health forum that I follow, none of the heart health enthusiasts are prepared to dismiss the theory that some sort of infection or other immunological provocation plays a pivotal role in CVD.

If a microbe, or gang thereof, is identified, further questions would arise. Wiki says that Coke switched from real cocaine to denatured cocaine in So it would have to have been something else and the water they use varies by bottling plant.

Bob, There are lots of infectious agents that are being considered as CVD perpetrators. You should find this interesting. That particular table is just bacteria.

I was a bit surprised that it omitted toxoplasmosis, as toxo has had a CVD association for decades in addition to likely neuro effects.

After a strenuous day of decorating, I have had a dreadful night with muscle cramps…. I will not present at the GP because it is not life threatening, but the same degree of pain occurring in the heart would have prompted a call.

I see a real connection between the muscle attacks you mention. Now, had it occurred in the heart in pre-modern days, I would have had to rest until the agony subsided.

But who would ever take that chance? Seems muscles have a hierarchy of importance, such that the heart muscle cannot be ignored, and left to its own devices to heal.

Just saying……. Bodies that deteriorate as they become older are a fact of life — the best we can hope for is to slow the rate of deterioration.

So where to start? That plus sufficient exercise to keep your body toned should work for most people. That is not to say that diet alone will prevent or resolve issues but that it is the only non-pharmaceutical approach that is likely to provide benefit ignoring the more obscure approaches such as meditation to a Western citizen.

What else can you change that is likely to provide benefit and, if you recognise the harm caused by the SAD, why would you not change?

There is no way such differences can be accounted for by diet alone so other factors must be involved. If not stress then what?

As for the rest of the world who knows? So many variables and, as always, the devil is in the detail. Not everyone will develop fatty streaks. My mother died at 57 not of natural causes and the pathologist told me that her arteries were completely free of atherosclerosis.

She fried everything in sunflower oil the Russian varieties. Were high oleic sunflower seeds were not around in Russia long before they were marketed as the newest greatest thing in the west?

No idea. I think sunflower oil has been around in Soviet Union for a while with southern Russia and Ukraine as major producers.

I do remember eating lots if it since it was the only oil available — salads, frying, etc. Kendrick — I am a long-standing member of Track Your Plaque recently renamed and I am a strong defender and follower of your theories.

Right now some on Dr. TYP being low carb high fat, no wheat, vitamin D, gut flora Some members want to dismiss your ideas because they read it as eat anything, diet is not an issue.

As a long time adherent of your writings I did wonder how long your phlegm could survive the plethora of diet advice. In my very humble opinion it is mostly complete bollocks.

I say this purely as an observation and an old person. Who says so? And where is the evidence to support this?

My brother is to his sixtieth decade, To my knowledge he has never knowingly eaten a vegetable. The odd one might have slipped by him in a late night curry.

The same is true of fruit unless you include fermented grapes. In my view the human body has evolved to chuck out whatever you like at it. So why the diet obsession?

People need to think they have some control over their health. Real medical research does not exist. Drug companies control it and junk anything that is not profitable.

Absurd hypothesis still exists. I had a heart attack 7 years ago. My surgery gives an annual MOT. Each time my doctor trots out the same irrelevant questions.

If I challenge her on anything she smiles sweetly and moves on to the next question. Frankly I feel embarrassed for her. It is supposed to be a heart clinic but I only go to see if blood test has thrown anything else.

This looks to be where heart disease and diabetes are linked. I see this series of blogs as a great attempt to involve us not only in understanding the pathways but also the arteries and underlying mechanisms of heart disease.

I wish I could have a doctor like Malcom Kendrick. I just want the doctor to check my thyroid I have a low thyroid once a year.

I feel fine. I just eat real food and not much sugar. I have severe anxiety at my doctors office, and feel unsafe there. If I have a heart attack, I want to ride it out and be put on medicines.

Maybe sometimes, they do. My so called bad habits have not changed since the 70s. I was put on statin on the grounds that during the next ten years I have a 30 percent chance of having a heart attack.

I have experienced those cramps — it is how I found this blog. Please bear this in mind if your doctor puts pressure on you to resume statins.

So starvation is a known stressor, high levels of sugar also triggers a huge reaction in the body that could also be considered stressful.

What about highly processed novel foods — maybe they are stressful for the body too? If we mainly eat the foods that have been available to us for thousands of years, then it is likely that our bodies can deal with those foods in a non-stressful way.

I feel the same about exposure to pollution, noise, lack of sunlight, sitting at desks all day.

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You can do sit-ups, press-ups, some abdominal crunches… But at the end of the day, what did you get? North America and Asia, revealed that sugar intake is a strong risk factor that contributes to higher breast cancer rates, particularly in older women.

Insulin and cancer Blood concentrations of fasting insulin, glucose, cholesterol and triglycerides in non-obese people suffering from colon, stomach and breast cancer were determined and compared with those of healthy non-obese people.

Insulin was also measured in tumours and non-cancerous tissues. Insulin and glucose with the exception of glucose in colon patients were significantly higher than in healthy people; blood cholesterol and triglycerides levels were lower.

Tumours contained 1. Cancer therapies should encompass regulating blood-glucose levels. This is best done via diet, supplements, and non-oral solutions for those.

References Chapter Twenty — Three — Cancer — disease of civilization Warburg O. On the origin of cancer cells. Science Shim H, et al. Rossi-Fanelli F, et al.

Abnormal substrate metabolism and nutritional strategies in cancer management. J Parenter Enteral Nutr ; Grant JP.

Proper use and recognized role of TPN in the cancer patient. A ; 6 4 Suppl : 6S-7S, 10S. Pedersen PL. Tumor mitochondria and the bioenergetics of cancer cells.

Exp Tumor Res , Tanchou S. Gaz d hop Par ; West J, et al. Malignancy and mortality in people with coeliac population based cohort study.

BMJ ; Seeley S, Diet and breast cancer; the possible connection with sugar consumption, Med Hyp ; Moerman CJ, el al. Dietary sugar intake in the aetiology of biliary tract cancer.

Int J Epidemiology Yam D, et al. Hyperinsulinemia in colon, stomach and breast cancer patients. Cancer Lett ; Selective quotatation of of reference [22].

This is a very puzzling result. It could mean that only these two cancers exhibit significant Warburg effect, which seems unlikely.

The overall hazard ratios were: for any malignancy 1. The increased risk was primarily in the first year after diagnosis, with the risk for only lymphoproliferative disease remaining significantly raised thereafter.

After excluding events in the year after diagnosis, the hazard ratio for malignancy was 1. This is unfortunately not true, or not the whole truth. Cancer cells are also fueled by proteins or fats or ketones.

They just need a bit time to adapt from one food source to another. Diana, are you saying Warburg was only partially correct? Thanks so much.

Such an ancient parasite as cancer will eat just anything. Excessive lipids and cholesterol in cancer cells are stored in lipid droplets LDs , and high LDs and stored-cholesteryl ester content in tumors11, 12, 13, 14 are now considered as hallmarks of cancer aggressiveness.

Paradoxically, some cancer cell lines also display addiction to glutamine despite the fact that glutamine is a nonessential amino acid that can be synthesized from glucose.

The high rate of glutamine uptake exhibited by glutamine-dependent cells does not appear to result solely from its role as a nitrogen donor in nucleotide and amino acid biosynthesis.

Instead, glutamine plays a required role in the uptake of essential amino acid and in maintaining activation of TOR kinase. Moreover, in many cancer cells, glutamine is the primary mitochondrial substrate and is required to maintain mitochondrial membrane potential and integrity as well as support of the NADPH production needed for redox control and macromolecular synthesis.

As such, ketone inhibitors should be designed as novel therapeutics to effectively treat advanced cancer patients, with tumor recurrence and metastatic disease.

This book, and reading a few things about the Warburg effect, still left me with the impression that all PET active cancers can be attacked by lowering glucose levels or disrupting glycolysis, and that those that are not PET active are slowly proliferating anyway.

I wonder if an approach similar to the use of multiple antibiotics is possible, in that the cancer is first driven into specialisation by a dietary change or some disruptor, and then killed off by another change that would not have killed the initial population prior to the first change.

How do I do it? Yes, there is clearly something else going on than too much glucose. Thanks everyone for all the comments whilst I have been away.

Seems to have been a very interesting discussion. Andy Harcombe had been approving comments for me. So thanks to him for this.

More work than he was expecting. It is great that everyone is so engaged and interested. Diana, I was thinking along the lines of e.

This is the beauty of this blog, that posts can take one in unexpected directions…. Yes, unexpected directions, but I think we have crossed the line again.

Enough of cancer. Kendrick: Bravo. Just joking. Very interested to see where your thinking is heading. Dr Kendrick, it seems we are still unable to itemise specific foodstuffs regarding cardiac problems, or many other maladies afflicting human beings.

By the time I am 70, I will have experienced many forms of illnesses causing death to close family members, young and old, close and distant acquaintances, short-stay and long-term patients in my care, and the countless unknown to me individuals who made it into the Times Obits, or the tail end of the BBC news.

There have been rich and poor. Tall and small. Fat and thin. Active and sedentary. Smokers and non-smokers. Drinkers and abstainers.

Intelligent and not-so bright. Saints and sinners. On and on. We will all die one day, but we are seeking to find the triggers causing poor health, so that we can avoid them, whilst looking for the elements which keep us healthy for as long as possible.

I conclude that these 2 lists are unlikely to overlap, and only by reading round the subjects of food and lifestyle choices, are we going to come up with a semblance of truth.

After all, it is not that long ago maybe 60 years or so , that some patients were being advised by GPs to smoke, making the Ancel Keys contribution to good health seem pretty benign in comparison!

My point? Please keep stimulating responses to your blog…. It is for us to choose who we think is the sincerest. Just to throw a spanner in the works though…..

And even more problematic……….. Though not in a way we can generalize. Everyone is different. One skinny person can eat ice cream and not gain a pound, whereas if I look at a delicious bowl, I gain 2 pounds!

The secret is finding out what diet and general foods, carbs, meats, etc. If we listen to what our body is telling us, i.

Ancel Keys supposedly changed his mind about saturated fat later in life, according to Dr. His famous 7 country study was really a 22 country study, he just ignored the other 15 which had higher amounts of fat in the diet.

Not exactly sure and how he got away with it is even more astounding. Would it be fair to say that Ancel Keys, abetted by government health propaganda, shortened more lives than Mao?

I fear it might be. Almost everything is caused by genes or germs. By the word diet are you ruling out nutritional value in our western diet.

I am anxious to see the comments on this one. If you eliminate diet as a useful tool for controlling heart disease, you take away what we feel we have some direct daily control over.

So, if not diet, then what? What factors can we actually take control of that will make the most difference?

Any difference? Low carb has huge benefits. I did a low carb diet for nearly two years because of the supposed advantage for endurance sport I cycle long distances.

But worse, it caused my heart rate to reduce and become erratic and for my body temperature to reduce. The final straw was when I collapsed due to the erratic heart rhythm and ended up in hospital.

They wanted me to have a pacemaker but I proved on a 5 day ECG Holter monitor that my rate and rhythm are normal on a high carb diet, donthey discharged me.

Or is that too simplistic? Our obsession with control through diet and other things in our lives causes stress which causes issues in the body CVD, Cancer, etc.

I am reading with great interest. They have done so for thousands of years. Sugar consumption has stagnated for quite some years now in most Western countries.

At a horrendous level, for sure. Mortality is a different story, but here treatment and other factors come into play. This is well within physiological norms.

And both are biochemically known to dramatically worsen our cardiovascular and overall health. Andrew, I agree entirely with you….

Catching your drift Dr K. As far as your a posts on heart disease are concerned you must be getting frustrated.

Diet does make a difference, but not necessarily here. So diabetes is not related to diet either? But I can easily believe that CVD is less affected by the particulars of what Blue Zoners eat than by their tight social communities, sunshine, exercise as part of daily life, etc.

One question: If CVD is caused by clotting problems, and some foods affect clotting omega 3s, vit K foods, etc. I guess I still find it hard to imagine that dietary factors make NO difference since we are, to some extent, what we eat.

It certainly is true that years of micro-analysis of vitamins, nutrients, antioxidants, etc. No consensus. It gets exhausting!!

I think it makes good sense to approach the question of health and disease from cell centric perspectives rather than dietary ones. If all our cells remain healthy then so do we.

But if cells become sick then the tissues and organs they comprise may trend to sickness and diseases too. Might it be the case that one of more factors could compromise cells ability to regenerate in precisely their own likeness?

Imprecise regeneration over successive generations of cells could then account for degeneration of cells with cells losing some of their specificity of purpose and function given to that type.

Cells start out in life as totipotent types that lack the necessary differentiation to account for the many types of cells that will develop as an embryo advances to become a foetus, as foetus advances to become a baby, and as a baby is born, becomes a child attains status of adult.

Robert O Becker did much pioneering research work on regeneration. He did so with the hope of being able to stimulate regeneration in the case of fractures where the process of regeneration and healing had stalled.

He did enjoy some successful outcomes in last chance patients. He established that the way cells regenerate may be influenced by the electrical environment that persists in the tissues that surround them.

The above should have the minds of truly interested parties wonder about the part that resting potential of cells may play in the regeneration of cells.

When the resting potential of cells is adequate cells regenerate with precision and maintain their allotted differentiation of type. If the resting potential of cells declines it has been suggested they trend away from their allotted differentiation.

Pertinent to the above is that oxygen is a potent stealer of electrons; while Earth is the great donor of electrons.

They are ions in other words and are typically represented by ions that are negatively charged. So if you collect exhaled breath, condense it, and test for pH the test will indicate alkalinity.

Exhaled breath condensates EBCs are typically alkaline. When a solution tests as alkaline that indicates net electro-negativity.

The net electro-negativity suggests oxygen breathing species lose electrons with every exhaled breath. This is the root of oxidative stress.

If electrons are being stolen from within us as ionised oxygen species because oxygen is a potent robber of electrons then that leaves aspects within us within our inner soup of biochemistry deficient in electrons.

There is simple visual analysis of blood samples that suggests oxidative stress of this kind results in a decline of zeta potential of blood cells.

Zeta potential and resting potential of cells amounts to the same thing, albeit set in contrasting contexts.

Blood cells equate to colloidal particles, and its adequate zeta potential that keeps colloidal particles in suspension. Ergo earthing restored zeta potential to blood cells.

Our progenitors and ancestors never had to concern themselves with oxidative stress. Just so long as they went about business as usual while being barefoot of shod with footwear crafted from natural materials then as fast as electrons exited the body with every exhaled breath replacement electrons could be sucked up through the soles of the feet from natures great electron donor, Earth.

Any tendency to assimilate electro-positivity within them and their inner soup was countered by the rise of electrons flowing from ground, through the feet, and into them.

Of course, the construction of dwellings has changed over the years, as has the extent and means to furnish them, and the construction of modern footwear now rarely utilises natural materials.

Instead rubber and plastic dominate. The modern human now has has effective contact with the great electron donor only on the rarest of occasions.

What has happened is that technological progress has sealed our fate. Oxidative stress is a natural phenomenon attributable to the properties of oxygen and the configuration of electrons in its outer shell.

The natural phenomenon that arises in all creatures that breathe air has a natural antidote. But in modernity we have lost the former traces and vestibules of effective contact.

Oxidative stress is a problem for us now when it never was before. Aspects of our inner soup that ought not to be electro-positive can trend that way so long as we remain so isolated from the great electron donor.

One very likely and significant prospect is that cells suffer decline of resting potential. If resting potential is chronically suppressed regeneration of cells will proceed, perhaps, in away that permits degeneration over successive generations.

So tissues and organs may suffer degeneration, then when they do we get sick and sicker. Now epidemiologist could turn their hand to something useful.

Those people who live in parts of the world where it is usual to go about business barefoot, or wearing footwear crafted from more natural materials, could be compared with the rest of us.

I consider an earthing sheet is a worthy investment. If they were able my cells would thank me for it. Interesting post Christopher, I have an earthed mouse mat and would love to source leather soled casual shoes, alas I may have to get some made.

The more I learn in this reading too difficult for medical students? Categorical statements make me revolt! This issue of the rise and fall of historic, reported CVD rates as a pointer to cause is confounding it seems to me.

If stress is a driving factor are we thinking that recent falls in rate reflect a lowering of stress at the population level?

It has been suggested that CVD may be communicable and that we are looking at an epidemic that is fading. It could be that aggregated data over a population is insufficiently granular.

CVD is tied to social class, gender etc. Perhaps the falling rate reflects inner shifts in the make up of the measured population?

And, of course as Dr. Kendrick as pointed to reporting inconsistencies. I have compiled a list of all Dr.

Kendrick, thanks for all your good work! Keep it up. I do wish he would somehow make the full list available — even by simply including a link to your list.

Igor, thank you ever so much for taking the time to compile this list and for sharing it with the rest of us. Thank you Dr Kendrick, I suspected as much regarding diet.

Totally intriguing. Lyon Renaud, de Lorgeril, et. Equally, if CVD is mainly caused by diet, how do you explain the French anomaly, or the fact that rice is a staple food for many people, or the fact that CVD rates have declined over many years?

Biochemistry is immensely complex — even before you factor in the bacteria in our guts — and yet something as simple simple as a cause, but the biochemistry will be complicated as stress clearly has a huge effect on CVD rates.

We are omnivores, and that must mean that our bodies have a lot of tolerance of variations of diet. Some of that has come out in these blog discussions — the innumerable feedback loops in the body that mean, for example, that if we consume more cholesterol, the liver makes less, or if we consume a little more salt, it is excreted etc etc.

So in this case, because the focus has been on diet, the models all relate to food. If the focus had been on the strict observance of religious rituals, I have little doubt that provided those rituals had enough complexity, someone would have made an excellent case that non-observance of this or that rite explained CVD!

There is a rough analogy with trying to fit some data to a formula with too many adjustable parameters. I realize the discussion is about CVD.

Keep in mind though, there are very good reasons to keep carbs within your tolerance and eat more fat.

From a presentation by Jeff Volek today:. Excellent series to maintain periodic motivation to search for answers. At 76 years it is important to slow down the ageing process asap.

My present beliefs about health always open to change is to follow the low carb diet. Then how much and when to eat has to be considered.

Thinking at the cell level can provide answers. Intermittent fasting such as Fast-5 gives cells a chance to rest and self clean via mTor regulated autophagy.

Keeping mitochondria happy is also important, adequate Mg and avoid linoleic acid. Stressed cells communicate their status to the liver and other organs and get an appropriate response.

Very complicated process and not fully understood, much more to learn how the body functions. In the meantime follow some basic principles that work for you.

Are supplements a waste of time as well. Tried everything to reduce my bp even low carb. Has Ornish since he published in The Lancet in been telling a complete load of porkies and diet has had little effect.

Men have far more heart disease than women. My intuition is that diet and lifestyle do matter, in complicated ways for different people.

Medicine is a special type of food also and while it might not be anywhere near as effective as we have been lead to believe, I would probably not be alive without metformin and big lifestyle changes.

Imagine that a similar pattern was relevant to cvd risk. In a population the genetic variants would be randomly distributed, the susceptibilities all mixed around.

Those who had a healthy upbringing even with the high risk genes might live long healthy lives, maximising their potential. Those who have bad diet or unfortunate diseases might not, even with hardier genetics.

A simple model based on that has two independent random variables ie susceptibility vs environment with the susceptibility heing truly random but the environment governed by lots of strange things that can vary widely by region; culture, diet, disease prevalence, family background, wealth, quality of health care ….

You have to rely on population statistics when what you really want to understand is individuals. Perhaps even not logical.

It certainly is possible to eat too much of any diet and what if you have a hfhchp highfathighcarbhighprotein hotchpotch with lots of badly prepared ingredients of dubious quality?

Not to mention a diet of statins. I get it now. This is Dr. Kendrick as agent provocateur. I predict at least comments for this post. Men get it more than women.

Older people get it more than younger people. Something to do with clotting. Nothing to do with diet. Virtually unknown before Rising to a peak in and falling away rapidly.

Grimes that an organism caused the CVD epidemic and it has run its course. Is it accepted that coronary artery plaques lead to blood supply insufficiency lead to heart muscle death, therefore it is enough to explain the formation of plaques?

On a subscription health forum that I follow, none of the heart health enthusiasts are prepared to dismiss the theory that some sort of infection or other immunological provocation plays a pivotal role in CVD.

If a microbe, or gang thereof, is identified, further questions would arise. Wiki says that Coke switched from real cocaine to denatured cocaine in So it would have to have been something else and the water they use varies by bottling plant.

Bob, There are lots of infectious agents that are being considered as CVD perpetrators. You should find this interesting.

That particular table is just bacteria. I was a bit surprised that it omitted toxoplasmosis, as toxo has had a CVD association for decades in addition to likely neuro effects.

After a strenuous day of decorating, I have had a dreadful night with muscle cramps…. I will not present at the GP because it is not life threatening, but the same degree of pain occurring in the heart would have prompted a call.

I see a real connection between the muscle attacks you mention. Now, had it occurred in the heart in pre-modern days, I would have had to rest until the agony subsided.

But who would ever take that chance? Seems muscles have a hierarchy of importance, such that the heart muscle cannot be ignored, and left to its own devices to heal.

Just saying……. Bodies that deteriorate as they become older are a fact of life — the best we can hope for is to slow the rate of deterioration.

So where to start? That plus sufficient exercise to keep your body toned should work for most people.

That is not to say that diet alone will prevent or resolve issues but that it is the only non-pharmaceutical approach that is likely to provide benefit ignoring the more obscure approaches such as meditation to a Western citizen.

What else can you change that is likely to provide benefit and, if you recognise the harm caused by the SAD, why would you not change?

There is no way such differences can be accounted for by diet alone so other factors must be involved. If not stress then what? As for the rest of the world who knows?

So many variables and, as always, the devil is in the detail. Not everyone will develop fatty streaks. My mother died at 57 not of natural causes and the pathologist told me that her arteries were completely free of atherosclerosis.

She fried everything in sunflower oil the Russian varieties. Were high oleic sunflower seeds were not around in Russia long before they were marketed as the newest greatest thing in the west?

No idea. I think sunflower oil has been around in Soviet Union for a while with southern Russia and Ukraine as major producers.

I do remember eating lots if it since it was the only oil available — salads, frying, etc. Kendrick — I am a long-standing member of Track Your Plaque recently renamed and I am a strong defender and follower of your theories.

Right now some on Dr. TYP being low carb high fat, no wheat, vitamin D, gut flora Some members want to dismiss your ideas because they read it as eat anything, diet is not an issue.

As a long time adherent of your writings I did wonder how long your phlegm could survive the plethora of diet advice. In my very humble opinion it is mostly complete bollocks.

I say this purely as an observation and an old person. Who says so? And where is the evidence to support this?

My brother is to his sixtieth decade, To my knowledge he has never knowingly eaten a vegetable. The odd one might have slipped by him in a late night curry.

The same is true of fruit unless you include fermented grapes. In my view the human body has evolved to chuck out whatever you like at it.

So why the diet obsession? People need to think they have some control over their health. Real medical research does not exist. Drug companies control it and junk anything that is not profitable.

Absurd hypothesis still exists. I had a heart attack 7 years ago. My surgery gives an annual MOT. Each time my doctor trots out the same irrelevant questions.

If I challenge her on anything she smiles sweetly and moves on to the next question. Frankly I feel embarrassed for her.

It is supposed to be a heart clinic but I only go to see if blood test has thrown anything else. This looks to be where heart disease and diabetes are linked.

I see this series of blogs as a great attempt to involve us not only in understanding the pathways but also the arteries and underlying mechanisms of heart disease.

I wish I could have a doctor like Malcom Kendrick. I just want the doctor to check my thyroid I have a low thyroid once a year. I feel fine. I just eat real food and not much sugar.

I have severe anxiety at my doctors office, and feel unsafe there. If I have a heart attack, I want to ride it out and be put on medicines.

Maybe sometimes, they do. My so called bad habits have not changed since the 70s. I was put on statin on the grounds that during the next ten years I have a 30 percent chance of having a heart attack.

I have experienced those cramps — it is how I found this blog. Please bear this in mind if your doctor puts pressure on you to resume statins.

So starvation is a known stressor, high levels of sugar also triggers a huge reaction in the body that could also be considered stressful.

What about highly processed novel foods — maybe they are stressful for the body too? If we mainly eat the foods that have been available to us for thousands of years, then it is likely that our bodies can deal with those foods in a non-stressful way.

I feel the same about exposure to pollution, noise, lack of sunlight, sitting at desks all day. Seems to me it all ties in somehow!

Once again Dr Kendrick has come up with another thought provoking article. I continue to be amazed and extremely thankful for the mental stimulation.

And diabetes is frequently associated with hyperglyceamia and high insulin, both of which are contributory factors.

Indeed, one piece of confidential information sorry but this is not in my ability to reveal the source that suggests that putting diabetics post-MI on insulin increases the risk of death.

I would love to reveal the hard data on this. There is also the contribution of ROS reactive oxygen species in this very multi-factorial condition and indeed in other chronic conditions as well.

Will it happen or will the concentration on pharmaceuticals continue? Try Googling why chimpanzees die of CVD in captivity at a seemingly alarming rate, despite a planned diet.

Hmmm, removed from the wild and put into a totally different environment. Food the same, or better, and yet they have a higher CVD rate.

Could it be the stress of the different environment? Could it? It is not easy to pin down precisely what is at work here, but the analogue with the human experience is still a striking one.

Money is interesting, because in the truly global and holistic sense there is none. All the financial liabilities of all the world equate to, and offset, al the financial assets.

Despite our freedom of expression and our freedom of movement we are nonetheless more captive that we can readily perceive. Inflammation being symptomatic as opposed to causal.

You would not credit it, but because we are light sensitive creatures many are in one way or another the ubiquity of artificial light has itself become a mixed blessing that can promote endocrine disruption.

We sit up too late, do not get enough sleep, the physiological efficacy of sleep is undermined, and we cannot sustain the kind of health we ought.

So what do they die of in the wild? It tells the story of Roseta in the US where, it seems, sense of community and social structures, protected the inhabitants from heart disease and other ills.

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